[HTML][HTML] DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity
Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that
uniquely define immune cell types and the mechanisms by which they are established …
uniquely define immune cell types and the mechanisms by which they are established …
CTLA4, PD-1, PD-L1, PD-L2, TIM-3, TIGIT, and LAG3 DNA methylation is associated with BAP1-aberrancy, transcriptional activity, and overall survival in uveal …
L de Vos, TMC Cano, R Zarbl, N Klümper… - Journal of …, 2022 - journals.lww.com
Uveal melanoma (UM) is an aggressive disease with poor response to oncological
treatment, including immunotherapy. Loss of the epigenetic modifier BRCA1-associated …
treatment, including immunotherapy. Loss of the epigenetic modifier BRCA1-associated …
Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia
JR Tejedor, C Bueno, M Vinyoles… - The Journal of …, 2021 - Am Soc Clin Investig
B cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. As
predicted by its prenatal origin, infant B-ALL (iB-ALL) shows an exceptionally silent DNA …
predicted by its prenatal origin, infant B-ALL (iB-ALL) shows an exceptionally silent DNA …
DNA methylation-based classification reveals difference between pediatric T-cell acute lymphoblastic leukemia and normal thymocytes
The development of next-generation sequencing (NGS) technologies has enabled genome-
wide analysis of T-cell acute lymphoblastic leukemia (T-ALL) and revealed genetic …
wide analysis of T-cell acute lymphoblastic leukemia (T-ALL) and revealed genetic …
Prognostic and predictive methylation biomarkers in HNSCC: Epigenomic diagnostics for head and neck squamous cell carcinoma (HNSCC)
A Franzen, F Bootz, D Dietrich - Hno, 2020 - Springer
Hintergrund Prognostische und prädiktive Biomarker sind für eine personalisierte
Therapiesteuerung beim Plattenepithelkarzinom des Kopf-und Halsbereichs (HNSCC) von …
Therapiesteuerung beim Plattenepithelkarzinom des Kopf-und Halsbereichs (HNSCC) von …
Classification of follicular-patterned thyroid lesions using a minimal set of epigenetic biomarkers
S Rodríguez-Rodero… - European Journal of …, 2022 - academic.oup.com
Objective The minimally invasive fine-needle aspiration cytology (FNAC) is the current gold
standard for the diagnosis of thyroid nodule malignancy. However, the correct discrimination …
standard for the diagnosis of thyroid nodule malignancy. However, the correct discrimination …
PD-L1 (CD274) promoter hypomethylation predicts immunotherapy response in metastatic urothelial carcinoma
ABSTRACT PD-L1 status assessed by immunohistochemistry (IHC) has failed to reliably
predict outcomes for patients with metastatic urothelial carcinoma (mUC) on immune …
predict outcomes for patients with metastatic urothelial carcinoma (mUC) on immune …
DNA methylation and cancer incidence: lymphatic–hematopoietic versus solid cancers in the Strong Heart Study
A Domingo-Relloso, T Huan, K Haack… - Clinical …, 2021 - Springer
Background Epigenetic alterations may contribute to early detection of cancer. We evaluated
the association of blood DNA methylation with lymphatic–hematopoietic cancers and, for …
the association of blood DNA methylation with lymphatic–hematopoietic cancers and, for …
Pathoepigenetics: the role of epigenetic biomarkers in disease pathogenesis
R Cacabelos - Pharmacoepigenetics, 2019 - Elsevier
Pathoepigenetics refers to the role that alterations in the epigenetic machinery exert on
human disease. Over 80% of complex disorders (cardiovascular, cerebral, metabolic …
human disease. Over 80% of complex disorders (cardiovascular, cerebral, metabolic …
Loss of MBD2 affects early T cell development by inhibiting the WNT signaling pathway
L Cheng, K Zhou, X Chen, J Zhou, W Cai… - Experimental Cell …, 2021 - Elsevier
DNA methylation alters the expression of certain genes without any alteration to the DNA
sequence and is a dynamic process during normal hematopoietic differentiation. As an …
sequence and is a dynamic process during normal hematopoietic differentiation. As an …