Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function
V Papadopoulos, M Baraldi, TR Guilarte… - Trends in …, 2006 - cell.com
The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely
distributed transmembrane protein that is located mainly in the outer mitochondrial …
distributed transmembrane protein that is located mainly in the outer mitochondrial …
Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury
The mitochondrial permeability transition is a key event in cell death. Intense research efforts
have been focused on elucidating the molecular components of the mitochondrial …
have been focused on elucidating the molecular components of the mitochondrial …
[HTML][HTML] Physiopathology of the permeability transition pore: Molecular mechanisms in human pathology
Mitochondrial permeability transition (MPT) is the sudden loss in the permeability of the
inner mitochondrial membrane (IMM) to low-molecular-weight solutes. Due to osmotic …
inner mitochondrial membrane (IMM) to low-molecular-weight solutes. Due to osmotic …
The 18 kDa translocator protein, microglia and neuroinflammation
GJ Liu, RJ Middleton, CR Hatty, WWY Kam… - Brain …, 2014 - Wiley Online Library
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is expressed in the injured brain. It has become known as an …
benzodiazepine receptor, is expressed in the injured brain. It has become known as an …
[HTML][HTML] The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death
Since its discovery in the 1970s, the mitochondrial permeability transition (MPT) has been
proposed to be a strategic regulator of cell death. Intense research efforts have focused on …
proposed to be a strategic regulator of cell death. Intense research efforts have focused on …
Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response
L Veenman, V Papadopoulos… - Current pharmaceutical …, 2007 - ingentaconnect.com
Due to its channel-like properties, the peripheral-type benzodiazepine receptor (PBR) has
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …
New approaches and therapeutics targeting apoptosis in disease
U Fischer, K Schulze-Osthoff - Pharmacological reviews, 2005 - ASPET
Apoptosis, the major form of cellular suicide, is central to various physiological processes
and the maintenance of homeostasis in multicellular organisms. Presumably, even more …
and the maintenance of homeostasis in multicellular organisms. Presumably, even more …
[HTML][HTML] The role of translocator protein TSPO in hallmarks of glioblastoma
Simple Summary The translocator protein (TSPO) has been under extensive investigation as
a specific marker in positron emission tomography (PET) to visualize brain lesions following …
a specific marker in positron emission tomography (PET) to visualize brain lesions following …
The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development
L Veenman, M Gavish - Pharmacology & therapeutics, 2006 - Elsevier
Peripheral-type benzodiazepine receptors (PBRs) are abundant in the cardiovascular
system. In the cardiovascular lumen, PBRs are present in platelets, erythrocytes …
system. In the cardiovascular lumen, PBRs are present in platelets, erythrocytes …
Role of the hypothalamic-pituitary-adrenal axis, glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products
JI Webster, EM Sternberg - Journal of Endocrinology, 2004 - joe.bioscientifica.com
The present study was undertaken to investigate heat stress protein (HSP)-70 mRNA
induction and p38 MAP kinase (MAPK) activity in response to ischaemic stress in the …
induction and p38 MAP kinase (MAPK) activity in response to ischaemic stress in the …