Integrated PK-PD and agent-based modeling in oncology

Z Wang, JD Butner, V Cristini, TS Deisboeck - Journal of pharmacokinetics …, 2015 - Springer
Mathematical modeling has become a valuable tool that strives to complement conventional
biomedical research modalities in order to predict experimental outcome, generate new …

Radiobiology of radiosurgery for neurosurgeons

C Tuleasca, M Tripathi, D Starnoni, RT Daniel… - Neurology …, 2023 - journals.lww.com
Stereotactic radiosurgery (SRS) is a precise focusing of radiation to a targeted point or larger
area of tissue. With advances in technology, the radiobiological understanding of this …

Murine-specific internal dosimetry for preclinical investigations of imaging and therapeutic agents

B Bednarz, J Grudzinski, I Marsh, A Besemer… - Health …, 2018 - journals.lww.com
There is a growing need to estimate the absorbed dose to small animals from preclinical
investigations involving diagnostic and therapeutic radiopharmaceuticals. This paper …

Chemoradionuclide Therapy with 186Re-Labeled Liposomal Doxorubicin: Toxicity, Dosimetry, and Therapeutic Response

A Soundararajan, A Bao, WT Phillips… - Cancer Biotherapy …, 2011 - liebertpub.com
This study was performed to determine the maximum tolerated dose (MTD) and therapeutic
effects of rhenium-186 (186Re)-labeled liposomal doxorubicin (Doxil), investigate …

Optimal preloading in radioimmunotherapy with anti‐CD45 antibody

P Kletting, T Kull, D Bunjes, M Luster… - Medical …, 2011 - Wiley Online Library
Purpose: Anti‐CD45 antibody is predominantly used in the treatment of acute leukemia.
CD45 is stably expressed on all leukocytes and their precursors, and therefore the liver and …

Optimization of vascular-targeting drugs in a computational model of tumor growth

J Gevertz - Physical Review E—Statistical, Nonlinear, and Soft …, 2012 - APS
A biophysical tool is introduced that seeks to provide a theoretical basis for helping drug
design teams assess the most promising drug targets and design optimal treatment …

Toxic effects of metallopharmaceuticals

S Novokmet, I Stojic, K Radonjic, M Savic… - … and Applied Biomedical …, 2017 - sciendo.com
Discovery of the metallopharmaceutical cisplatin and its use in antitumour therapy has
initiated the rational design and screening of metal-based anticancer agents as potential …

Development of a PET-Based Theranostic for Drug-Resistant BRAFV600EMelanoma

MC Bellavia - 2023 - search.proquest.com
Targeted radiopharmaceutical therapy (TRT) involving systemic administration of a tumor-
selective agent labeled with a radionuclide has demonstrated considerable promise for …

Development of a treatment planning algorithm for peptide-receptor radionuclide therapy considering multiple tumour lesions and organs at risk

LD Jiménez Franco - 2018 - archiv.ub.uni-heidelberg.de
Peptide-receptor radionuclide therapy (PRRT) is a modality of molecular radiotherapy in
which patients are administered with radiolabelled peptides targeting peptide-receptors …

Möglichkeiten zur Verbesserung der Dosimetrie und Therapieplanung in der Molekularen Radiotherapie durch maschinelles Lernen

LD Jiménez-Franco, P Kletting… - Der Nuklearmediziner, 2019 - thieme-connect.com
Die Molekulare Strahlentherapie ist eine systemische oder lokoregionäre Therapie, bei der
dem Patienten ein Radionuklid oder ein radioaktiv markiertes Arzneimittel verabreicht wird …