For the past 50 years, fungal secondary metabolites have revolutionized medicine yielding
blockbuster drugs and drug leads of enormous therapeutic and agricultural potential. Since …

In human males, TS plays a key role in maintaining health and sexual functioning.
Cholesterol acts as a precursor molecule for its biosynthesis. The microbial …

The environmental fate and bioavailability of progesterone, a steroid hormone known to
cause endocrine-disrupting effects in aquatic organisms, is of growing concern due to its …

The research on the synthesis of steroids and its derivatives is of high interest due to their
clinical applications. A particular focus is given to molecules bearing a D-ring lactone like …

Biotransformation of Progesterone by Whole Cells of Filamentous Fungi Aspergillus brasiliensis
- PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

Biotechnological transformation of steroids using enzyme systems of microorganisms is
often the only possible method to modify the molecule in the industrial production of steroid …

Microbiological synthesis of 7α-and 7β-hydroxy derivatives of testololactone and
testolactone was developed based on bioconversion of dehydroepiandrosterone (DHEA) by …

Thirty-three isolates belonging to six species of the genus Trichoderma were tested for the
ability to hydroxylate progesterone to 11α-, 11β-, 11α, 17α-and 6β, 17α-derivatives, and …

There is an ever-increasing demand of newer and improved drugs from biological sources
to cater to the bio-pharmaceutical sector. Among various other resources, fungal species …

Aspergillus tamarii contains an endogenous lactonization pathway which can transform
progesterone to testololactone in high yield through a sequential four step enzymatic …