The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory
form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The …

The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation
of the inflammatory response causes oxidative stress, alterations in mitochondrial energy …

The NOD-like receptor (NLR) family, pyrin domain–containing protein 3 (NLRP3)
inflammasome is a component of the inflammatory process, and its aberrant activation is …

The dysregulation of NLRP 3 inflammasome can cause uncontrolled inflammation and drive
the development of a wide variety of human diseases, but the medications targeting NLRP 3 …

Neurodegenerative diseases are chronic, progressive disorders that occur in the central
nervous system (CNS). They are characterized by the loss of neuronal structure and function …

Inflammasomes, key molecular regulators that play an important role in inflammation, consist
of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 …

Severe asthma (SA) is a chronic lung disease characterized by recurring symptoms of
reversible airflow obstruction, airway hyper-responsiveness (AHR), and inflammation that is …

Background/Aims. NLRP3 inflammasome, an inflammasome which consists of nucleotide‐
binding oligomerization domain‐(Nod‐) like receptor3 (NLRP3) scaffold, apoptosis …

Inflammasomes are intracellular protein complexes, members of the innate immune system,
and their activation and regulation play an essential role in maintaining homeostatic …

The findings reviewed in this article expand our understanding of the relevance of elevated
plasma oxalate levels leading to inflammasome activation. We propose that inhibiting …