Major progress has been made in recent years in the development of Hedgehog (Hh)
pathway inhibitors for the treatment of patients with cancer. Promising clinical trial results …

Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …

The endoderm germ layer contributes to the respiratory and gastrointestinal tracts and to all
of their associated organs. Over the past decade, studies in vertebrate model organisms …

Ligand-dependent activation of the hedgehog (Hh) signalling pathway has been associated
with tumorigenesis in a number of human tissues,,,,,,. Here we show that, although previous …

In this review, we present an overview of intestinal development and cellular differentiation
of the intestinal epithelium. The review is separated into two sections: Section one …

The intestinal epithelium comprises a monolayer of polarised columnar cells organised
along the cryptvillus axis. Intestinal stem cells reside at the base of crypts and are …

The mesenchymal elements of the intestinal lamina propria reviewed here are the
myofibroblasts, fibroblasts, mural cells (pericytes) of the vasculature, bone marrow–derived …

In this Review we summarize our current understanding of the biology of mesenchymal cells
of the intestinal lamina propria focusing mainly on fibroblasts and myofibroblasts. The topics …

Cyclopamine is a teratogenic steroidal alkaloid, which inhibits the Hedgehog (Hh) signaling
pathway by targeting the Smoothened (Smo) receptor. Suppression of Hh signaling with …