Tumour necrosis factor (TNF) is a primary mediator of inflammatory processes by facilitating
cell death, immune cell activation and triggering of inflammation. In the cancer context …

Simple Summary The prevalence of nonalcoholic fatty liver disease (NAFLD)-associated
hepatocellular carcinoma (HCC) is rapidly increasing, following the growing prevalence of …

Soluble receptors are soluble forms of receptors found in the extracellular space. They have
emerged as pivotal regulators of cellular signaling and disease pathogenesis. This review …

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant
disease with low overall survival; chemotherapy and immunotherapy have limited efficacy …

Background Taste disorders are common in patients with cancer undergoing systemic
therapy, persist during treatment and are associated with reduced food intake, increasing …

Glioblastoma multiforme (GBM) represents the most common and aggressive malignant
form of brain tumour in adults and is characterized by an extremely poor prognosis with …

Cancer is the leading cause of death worldwide, accounting for nearly 10 million deaths
every year. Immune checkpoint blockade approaches have changed the therapeutic …

Simple Summary This longitudinal cohort study investigates the role of soluble Tumor
Necrosis Factor Receptor 1 (sTNF-R1) in non-small-cell lung cancer (NSCLC) patients …

Later-life health is patterned by socioeconomic influences across the lifecourse. However,
the pathways underlying the biological embedding of socioeconomic status (SES) and its …

Dendritic cell (DC)-based anti-cancer vaccines have been ineffectual as a monotherapy for
invasive cancer. We therefore formulated a combined therapy approach that exploits the …