It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …

The human body is constantly exposed to microorganisms, which entails manifold
interactions between human cells and diverse commensal or pathogenic bacteria. The …

Current antibiotics, derived mainly from natural sources, inhibit a narrow spectrum of cellular
processes, namely DNA replication, protein synthesis, and cell wall biosynthesis. With the …

During pathogenesis, M ycobacterium tuberculosis (Mtb) colonizes environments, such as
the macrophage or necrotic granuloma, that are acidic and rich in cholesterol and fatty acids …

The ability of science and medicine to control the pathogen Mycobacterium tuberculosis
(Mtb) requires an understanding of the complex host environment within which it resides …

Nitrogen metabolism of Mycobacterium tuberculosis (Mtb) is crucial for the survival of this
important pathogen in its primary human host cell, the macrophage, but little is known about …

Pseudomonas aeruginosa is an opportunistic human pathogen, particularly noted for
causing infections in the lungs of people with cystic fibrosis (CF). Previous studies have …

Two parallel revolutions were born in the golden era of antibiotics (~ 1940 to 1960). One
was a revolution in medicine as physicians went to war with microbes. The second was a …

Mycobacterium tuberculosis (Mtb) uses alveolar macrophages as primary host cells during
infection. In response to an infection, macrophages switch from pyruvate oxidation to …