Methods We included full articles and book chapters published in English on PubMed with
references to “hypoxic ischemic encephalopathy”,“birth asphyxia”,“therapeutic hypothermia” …

Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early
hours lack objective measurement tools. Therefore, this systematic review aims to identify …

Background: To discover novel metabolic biomarkers of ischemic stroke (IS), we carried out
a two-stage metabolomic profiling of IS patients and healthy controls using untargeted and …

Despite advances in neonatal care to prevent neonatal brain injury and
neurodevelopmental impairment, predicting long-term outcome in neonates at risk for brain …

Background Infants with moderate and severe neonatal encephalopathy (NE) frequently
suffer from long-term adverse outcomes. We hypothesize that the urinary metabolome of …

A study was performed to determine early metabolomic markers of ischemic hypoxic
encephalopathy (HIE) using a Rice–Vannucci model for newborn rats. Dried blood spots …

Background The pathobiological mechanisms associated with perinatal asphyxia and
hypoxic-ischemic encephalopathy are complex and poorly understood. The metabolic …

Predicting survival in very preterm infants is critical in clinical medicine and parent
counseling. In this prospective cohort study involving 96 very preterm infants, we evaluated …

There is a need for feasible and non-invasive diagnostics in perinatal asphyxia.
Metabolomics is the study of small molecular weight products of cellular metabolism that …

Hypoxic‐ischemic encephalopathy (HIE) is a common neurological syndrome in newborns
with high mortality and morbidity. Therapeutic hypothermia (TH), which is standard of care …