The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

The homochirality of biomolecules in nature, such as DNA, RNA, peptides and proteins, has
played a critical role in establishing and sustaining life on Earth. This chiral bias has also …

Quantum information science and engineering (QISE)—which entails the use of quantum
mechanical states for information processing, communications, and sensing—and the area …

Contemporary chemical protein synthesis has been dramatically advanced over the past few
decades, which has enabled chemists to reach the landscape of synthetic …

Nature has developed a plethora of protein machinery to operate and maintain nearly every
task of cellular life. These processes are tightly regulated via post‐expression modifications …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Total chemical protein synthesis provides access to entire D‐protein enantiomers enabling
unique applications in molecular biology, structural biology, and bioactive compound …

Chemical ubiquitination is an effective approach for accessing structurally defined, atypical
ubiquitin (Ub) chains that are difficult to prepare by other techniques. Herein, we describe a …

Protein ubiquitination regulates almost every process in eukaryotic cells. The study of the
many enzymes involved in the ubiquitination system and the development of ubiquitination …

Mirror-image proteins and peptides composed of D-amino acids are garnering increasing
attention as diagnostic agents and drug candidates due to their higher stability and lower …