Success with B cell depletion using rituximab has proven the concept that B lineage cells
represent a valid target for the treatment of autoimmune diseases, and has promoted the …

Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types
of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of …

Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's
lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and …

Immunoglobulin (Ig) M+ IgD+ B cells are generally assumed to represent antigen-
inexperienced, naive B cells expressing variable (V) region genes without somatic …

Genomic instability promotes tumorigenesis and can occur through various mechanisms,
including defective segregation of chromosomes or inactivation of DNA mismatch repair …

Hodgkin's lymphoma was first described in 1832. The aetiology of this lymphoma, however,
remained enigmatic for a long time. Only within the past 10 years has the B-cell nature of the …

The most common human leukemia is B cell chronic lymphocytic leukemia (CLL), a
malignancy of mature B cells with a characteristic clinical presentation but a variable clinical …

B cell–derived chronic lymphocytic leukemia (B-CLL) represents a common malignancy
whose cell derivation and pathogenesis are unknown. Recent studies have shown that> …

Reciprocal chromosomal translocations involving the immunoglobulin (Ig) loci are a
hallmark of most mature B cell lymphomas and usually result in dysregulated expression of …

The origin of human lymphomas has been studied by various approaches, including
histology and immunophenotyping. In some types of lymphoma these studies suggested the …