The specificity of cellular responses to receptor stimulation is encoded by the spatial and
temporal dynamics of downstream signalling networks. Temporal dynamics are coupled to …

Complex models of biochemical reaction systems have become increasingly common in the
systems biology literature. The complexity of such models can present a number of …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Rule-based modeling involves the representation of molecules as structured objects and
molecular interactions as rules for transforming the attributes of these objects. The approach …

Formalized rules for protein-protein interactions have recently been introduced to represent
the binding and enzymatic activities of proteins in cellular signaling. Rules encode an …

Signaling pathways control cell fate decisions that ultimately determine the behavior of
cancer cells. Therefore, the dynamics of pathway activity may contain prognostically relevant …

Mitogen-activated protein kinase (MAPK) cascades control cell fate decisions, such as
proliferation, differentiation, and apoptosis by integrating and processing intra-and …

Crosstalk mechanisms have not been studied as thoroughly as individual signaling
pathways. We exploit experimental and computational approaches to reveal how a …

Complex dynamical reaction networks consisting of many components that interact and
produce each other are difficult to understand, especially, when new component types may …

The advancements in “omics”(proteomics, genomics, lipidomics, and metabolomics)
technologies have yielded large inventories of genes, transcripts, proteins, and metabolites …