Improving the survival of patients with osteosarcoma has long proved challenging, although
the treatment of this disease is on the precipice of advancement. The increasing feasibility of …

Medulloblastoma is the most common pediatric malignant brain tumor. Advances in
molecular profiling have uncovered significant heterogeneity among medulloblastomas and …

Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal
neoplasms of the hindbrain with strong links to early development of the hindbrain 1, 2, 3, 4 …

Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into
biologically distinct subgroups, suggesting that a personalized approach to therapy would …

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …

Background Meningiomas are the most common primary intracranial tumor in adults.
Clinical care is currently guided by the World Health Organization (WHO) grade assigned to …

Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct
molecular subgroups. Whereas genomic characteristics of these subgroups are well …

PURPOSE SJMB03 (ClinicalTrials. gov identifier: NCT00085202) was a phase III risk-
adapted trial that aimed to determine the frequency and clinical significance of biological …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Study of the origin and development of cerebellar tumours has been hampered by the
complexity and heterogeneity of cerebellar cells that change over the course of …