Biological responses are determined by information processing at multiple and highly
interconnected scales. Within a tissue the individual cells respond to extracellular stimuli by …

Drug-induced liver injury (DILI) has become a major problem for patients and for clinicians,
academics and the pharmaceutical industry. To date, existing hepatotoxicity test systems are …

Skin injury repair is a dynamic process involving a series of interactions over time and
space. Linking human physiological processes with materials' changes poses a significant …

In the liver tumor necrosis factor (TNF)-induced signaling critically regulates the immune
response of non-parenchymal cells as well as proliferation and apoptosis of hepatocytes via …

AIM: To analyze the role of CYLD for receptor-mediated cell death of murine hepatocytes in
acute liver injury models. METHODS: Hepatocyte cell death in CYLD knockout mice (CYLD …

肝损伤是临床上的常见病, 各种物理和化学因素均可导致急, 慢性肝损伤, 严重或持续的肝损伤
最终可导致急性肝功能衰竭, 危机患者生命. 肝损伤及其修复一直是肝脏疾病研究的前沿热点 …

Gut‐derived bacterial lipopolysaccharides (LPS) stimulate the secretion of tumour necrosis
factor (TNF) from liver macrophages (MC s), liver sinusoidal endothelial cells (LSEC s) and …

Historically, hepatocarcinogenesis has been regarded as a linear process developing
against a background of dysfunctional oncogenes or tumor suppressor genes. However …

Where is The Cure for Cancer? Have you ever wondered why in the past 100 years a cure
for cancer has not been found? You're not alone! We've all lost someone we love to cancer …

Gut-derived bacteria enter the liver via the portal vein where they induce an innate immune
response leading to inflammation. Lipopolysaccharide, a part the bacterial cell wall …