Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in
neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They …

Abstract Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the
1970s. Because of its function by removing acetylated groups from histones in the presence …

Ruthenium complexes are an important class that has multiple catalytic and biological
applications. Ruthenium has a remarkably broad and diversified chemical spectrum. In the …

The structures and biological activities of naturally occurring 3‐alkenyl‐oxindoles are
reviewed. Important man‐made3‐alkenyl‐oxindoles are covered, particularly those with …

Sirtuins are a class of enzymes with nicotinamide adenine dinucleotide (NAD)-dependent
protein lysine deacylase function. By deacylating various substrate proteins, including …

There is a growing recognition of the importance of protein kinases in the control of
alternative splicing. To define the underlying regulatory mechanisms, highly selective …

Sirtuins are NAD+‐dependent protein deacylases that cleave off acetyl, as well as other acyl
groups, from the ε‐amino group of lysines in histones and other substrate proteins. Seven …

There is considerable evidence suggesting that epigenetic mechanisms may mediate
development of chronic inflammation by modulating the expression of pro-inflammatory …

A simple and highly efficient method has been developed for the synthesis of 3, 3-diindolyl
oxyindoles by the reaction of indoles with isatin or 5-fluoro isatin using a catalytic amount …

Histone modifying enzymes have vital roles in the growth and survival of both parasites and
humans. Targeting the epigenome can be a new strategy for the treatment of parasitic …