Atrial fibrillation is a common heart rhythm disorder that leads to an increased risk for stroke
and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic …

Atrial fibrillation (AF) is the most common arrhythmia with ever-increasing public health
impact. 1 Over 50 years of observation in the Framingham Heart Study (FHS), there is a 4 …

To identify genetic variation underlying atrial fibrillation, the most common cardiac
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …

Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …

Importance Atrial fibrillation (AF) is the most common arrhythmia affecting 1% of the
population. Young individuals with AF have a strong genetic association with the disease …

Fine-mapping in genome-wide association studies attempts to identify causal SNPs from a
set of candidate SNPs in a local genomic region of interest and is commonly performed in …

Background: Truncating variants in the Titin gene (TTNtvs) are common in individuals with
idiopathic dilated cardiomyopathy (DCM). However, a comprehensive genomics-first …

Summary The Trøndelag Health Study (HUNT) is a population-based cohort of∼ 229,000
individuals recruited in four waves beginning in 1984 in Trøndelag County, Norway …

Genetic studies of blood pressure (BP) to date have mainly analyzed common variants
(minor allele frequency> 0.05). In a meta-analysis of up to~ 1.3 million participants, we …

Background Observational studies have identified height as a strong risk factor for atrial
fibrillation, but this finding may be limited by residual confounding. We aimed to examine …