Is high folic acid intake a risk factor for autism?—a review
D Wiens, MC DeSoto - Brain sciences, 2017 - mdpi.com
Folate is required for metabolic processes and neural development. Insuring its adequate
levels for pregnant women through supplementation of grain-based foods with synthetic folic …
levels for pregnant women through supplementation of grain-based foods with synthetic folic …
Folic acid and autism: a systematic review of the current state of knowledge
Folic acid has been identified to be integral in rapid tissue growth and cell division during
fetal development. Different studies indicate folic acid's importance in improving childhood …
fetal development. Different studies indicate folic acid's importance in improving childhood …
High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism
Dietary folate is a major source of methyl groups required for DNA methylation, an
epigenetic modification that is actively maintained and remodeled during spermatogenesis …
epigenetic modification that is actively maintained and remodeled during spermatogenesis …
High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory …
RH Bahous, NM Jadavji, L Deng… - Human molecular …, 2017 - academic.oup.com
Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for
methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic …
methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic …
[HTML][HTML] Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4–5 y of age: the prospective birth cohort Infancia y …
D Valera-Gran, EM Navarrete-Munoz… - The American journal of …, 2017 - Elsevier
Background The benefits of the use of folic acid supplements (FASs) during the
periconception period to prevent neural tube defects and to ensure normal brain …
periconception period to prevent neural tube defects and to ensure normal brain …
Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study
Selenium (Se) is an essential trace element involved in various biological processes,
including neurodevelopment. Available literature indicates that both Se deficiency and …
including neurodevelopment. Available literature indicates that both Se deficiency and …
Effects of 900-MHz radiation on the hippocampus and cerebellum of adult rats and attenuation of such effects by folic acid and Boswellia sacra
The radiation emitted from mobile phones has various deleterious effects on human health.
This study was conducted to evaluate the effects of exposure to the 900-MHz radiation …
This study was conducted to evaluate the effects of exposure to the 900-MHz radiation …
Risk of excess maternal folic acid supplementation in offspring
Folate, also known as vitamin B9, facilitates the transfer of methyl groups among molecules,
which is crucial for amino acid metabolism and nucleotide synthesis. Adequate maternal …
which is crucial for amino acid metabolism and nucleotide synthesis. Adequate maternal …
Excess Folic Acid Supplementation Before and During Pregnancy and Lactation Activates Fos Gene Expression and Alters Behaviors in Male Mouse Offspring
D Chu, L Li, Y Jiang, J Tan, J Ji, Y Zhang… - Frontiers in …, 2019 - frontiersin.org
Periconceptional folic acid (FA) supplementation is recommended to prevent neural tube
defects and other birth defects. After 20 years mandate food fortification with FA, serum …
defects and other birth defects. After 20 years mandate food fortification with FA, serum …
Excess folic acid supplementation before and during pregnancy and lactation alters behaviors and brain gene expression in female mouse offspring
X Yang, W Sun, Q Wu, H Lin, Z Lu, X Shen, Y Chen… - Nutrients, 2021 - mdpi.com
Use of folic acid (FA) during early pregnancy protects against birth defects. However, excess
FA has shown gender-specific neurodevelopmental toxicity. Previously, we fed the mice with …
FA has shown gender-specific neurodevelopmental toxicity. Previously, we fed the mice with …