Is high folic acid intake a risk factor for autism?—a review

D Wiens, MC DeSoto - Brain sciences, 2017 - mdpi.com
Folate is required for metabolic processes and neural development. Insuring its adequate
levels for pregnant women through supplementation of grain-based foods with synthetic folic …

Folic acid and autism: a systematic review of the current state of knowledge

B Hoxha, M Hoxha, E Domi, J Gervasoni, S Persichilli… - Cells, 2021 - mdpi.com
Folic acid has been identified to be integral in rapid tissue growth and cell division during
fetal development. Different studies indicate folic acid's importance in improving childhood …

High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism

M Aarabi, MC San Gabriel, D Chan… - Human molecular …, 2015 - academic.oup.com
Dietary folate is a major source of methyl groups required for DNA methylation, an
epigenetic modification that is actively maintained and remodeled during spermatogenesis …

High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory …

RH Bahous, NM Jadavji, L Deng… - Human molecular …, 2017 - academic.oup.com
Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for
methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic …

[HTML][HTML] Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4–5 y of age: the prospective birth cohort Infancia y …

D Valera-Gran, EM Navarrete-Munoz… - The American journal of …, 2017 - Elsevier
Background The benefits of the use of folic acid supplements (FASs) during the
periconception period to prevent neural tube defects and to ensure normal brain …

Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study

ASE Lee, Y Ji, R Raghavan, G Wang, X Hong… - Autism …, 2021 - Wiley Online Library
Selenium (Se) is an essential trace element involved in various biological processes,
including neurodevelopment. Available literature indicates that both Se deficiency and …

Effects of 900-MHz radiation on the hippocampus and cerebellum of adult rats and attenuation of such effects by folic acid and Boswellia sacra

EG Kivrak, BZ Altunkaynak, I Alkan, KK Yurt… - Journal of microscopy …, 2017 - Elsevier
The radiation emitted from mobile phones has various deleterious effects on human health.
This study was conducted to evaluate the effects of exposure to the 900-MHz radiation …

Risk of excess maternal folic acid supplementation in offspring

X Xu, Z Zhang, Y Lin, H Xie - Nutrients, 2024 - mdpi.com
Folate, also known as vitamin B9, facilitates the transfer of methyl groups among molecules,
which is crucial for amino acid metabolism and nucleotide synthesis. Adequate maternal …

Excess Folic Acid Supplementation Before and During Pregnancy and Lactation Activates Fos Gene Expression and Alters Behaviors in Male Mouse Offspring

D Chu, L Li, Y Jiang, J Tan, J Ji, Y Zhang… - Frontiers in …, 2019 - frontiersin.org
Periconceptional folic acid (FA) supplementation is recommended to prevent neural tube
defects and other birth defects. After 20 years mandate food fortification with FA, serum …

Excess folic acid supplementation before and during pregnancy and lactation alters behaviors and brain gene expression in female mouse offspring

X Yang, W Sun, Q Wu, H Lin, Z Lu, X Shen, Y Chen… - Nutrients, 2021 - mdpi.com
Use of folic acid (FA) during early pregnancy protects against birth defects. However, excess
FA has shown gender-specific neurodevelopmental toxicity. Previously, we fed the mice with …