Mechanotransduction research has focused historically on how externally applied forces
can affect cell signalling and function. A growing body of evidence suggests that contractile …

From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …

Cells in tissues are mechanically coupled both to the ECM and neighboring cells, but the
coordination and interdependency of forces sustained at cell-ECM and cell–cell adhesions …

Axis elongation in Drosophila occurs through polarized cell rearrangements driven by
actomyosin contractility. Myosin II promotes neighbor exchange through the contraction of …

Contractile forces generated by the actomyosin cytoskeleton within individual cells
collectively generate tissue-level force during epithelial morphogenesis. During Drosophila …

Force production and the propagation of stress and strain within embryos and organisms are
crucial physical processes that direct morphogenesis. In addition, there is mounting …

Understanding cell morphogenesis during metazoan development requires knowledge of
how cells and the extracellular matrix produce and respond to forces. We investigated how …

Mechanisms that control cell-cycle dynamics during tissue regeneration require elucidation.
Here we find in zebrafish that regeneration of the epicardium, the mesothelial covering of the …

Embryonic development involves global changes in tissue shape and architecture that are
driven by cell shape changes and rearrangements within cohesive cell sheets …

Dynamic remodeling of the actin cytoskeleton is required for both development and tissue
homeostasis. While fixed image analysis has provided significant insight into such events, a …