CRISPR/Cas9 is an effective gene editing tool with broad applications for the prevention or
treatment of numerous diseases. It depends on CRISPR (clustered regularly interspaced …

A new era of medical technology in cancer treatment is a directly specific modification of
gene expression in tumor cells by nucleic acid delivery. Currently, the main challenge to …

Designing suitable nano-carriers for simultaneous gene delivery and tracking is in the
research priorities of the molecular medicine. Non-toxic graphene quantum dots (GQDs) …

Genomic DNA sequences provide unique target sites, with high druggability value, for
treatment of genetically-linked diseases like cancer. B-cell lymphoma protein-2 (BCL-2) …

Abstract Chitosan/alginate (Chi/Alg) nanoparticles as a non-viral vector for the Smad4
encoding plasmid were optimized utilizing D-optimal design based on the …

Here, a newly modified chitosan tetrazole was synthesized and fully characterized for
CRISPR technology since by increasing the ratio of nitrogen to other elements, the …

Together with the nucleus, the mitochondrion has its own genome. Mutations in
mitochondrial DNA are responsible for a variety of disorders, including neurodegenerative …

The efficiency of gene therapy is often dictated by the gene delivery system. Cationic
polymers are essential elements of gene delivery systems. The relatively cheap cationic …

Researchers still hold for the development of a safety and advanced delivery system able of
efficient therapeutic action. The co-delivery of different payloads is part of this strategy and …

Gene therapy is a promising strategy for treatments of various diseases. Efficient and safe
introduction of therapeutic genes into targeted cells is essential to realize functions of the …