Metformin blocks the absorption of vitamin B12 through a mechanism that has not been
established but could be because of interference with the calcium‐dependent binding of the …

Aim Metformin is the most widely used oral hypoglycaemic drug, but it may lower B 12
status, which could have important clinical implications. We undertook a systematic review …

Context: Vitamin B12 deficiency may occur with metformin treatment, but few studies have
assessed risk with long-term use. Objective: To assess the risk of B12 deficiency with …

Background: Metformin can cause serum vitamin B12 deficiency, but studies on the
influence of its duration and dose are lacking. We investigated vitamin B12 deficiency in …

Pharmacometabolomics (PMx) studies use information contained in metabolic profiles (or
metabolome) to inform about how a subject will respond to drug treatment. Genome, gut …

Metformin is the first-line treatment for many people with type 2 diabetes mellitus (T2DM)
and gestational diabetes mellitus (GDM) to maintain glycaemic control. Recent evidence …

Aims To compare the prevalence of vitamin B12 deficiency and peripheral neuropathy
between two groups of type 2 diabetes mellitus (T2DM) patients treated with or without …

The long-term use of prescription and over-the-counter drugs can induce subclinical and
clinically relevant micronutrient deficiencies, which may develop gradually over months or …

CONTEXT AND OBJECTIVE: The prevalence of vitamin B12 deficiency varies from 5.8% to
30% among patients undergoing long-term treatment with metformin. Because of the paucity …

Objective Vitamin B12 deficiency resulting from metformin use has been demonstrated in
multiple studies. In this study, we aimed to evaluate the prevalence of vitamin B12 deficiency …