Recent advances in microfluidic technology for bioanalysis and diagnostics
Microfluidics has become a mature technology, providing an excellent toolbox for the
handling and manipulation of fluid samples, suspended cells, and particles. About 30 years …
handling and manipulation of fluid samples, suspended cells, and particles. About 30 years …
[HTML][HTML] Organs-on-chips technologies–A guide from disease models to opportunities for drug development
Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …
human physiopathology with striking discrepancies in estimating drug efficacy and side …
Advances in microfluidic in vitro systems for neurological disease modeling
PM Holloway, S Willaime‐Morawek… - Journal of …, 2021 - Wiley Online Library
Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …
death worldwide. Despite significant research efforts, neurology remains one of the most …
[HTML][HTML] Brain-on-a-chip: A history of development and future perspective
Since the advent of organ-on-a-chip, many researchers have tried to mimic the physiology of
human tissue on an engineered platform. In the case of brain tissue, structural connections …
human tissue on an engineered platform. In the case of brain tissue, structural connections …
Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance
Recent developments of organoids engineering and organ-on-a-chip microfluidic
technologies have enabled the recapitulation of the major functions and architectures of …
technologies have enabled the recapitulation of the major functions and architectures of …
Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies
Over the past 15 years, the field of oncology research has witnessed significant progress in
the development of new cell culture models, such as tumor-on-chip (ToC) systems. In this …
the development of new cell culture models, such as tumor-on-chip (ToC) systems. In this …
[HTML][HTML] In situ sensors for blood-brain barrier (BBB) on a chip
The blood-brain barrier (BBB) is critical for the central nervous system, as its integrity
protects neurons and other brain cells from harmful toxicants and disease-associated …
protects neurons and other brain cells from harmful toxicants and disease-associated …
Proteinaceous hydrogels for bioengineering advanced 3D tumor models
The establishment of tumor microenvironment using biomimetic in vitro models that
recapitulate key tumor hallmarks including the tumor supporting extracellular matrix (ECM) is …
recapitulate key tumor hallmarks including the tumor supporting extracellular matrix (ECM) is …
Development of human-derived, three-dimensional respiratory epithelial tissue constructs with perfusable microvasculature on a high-throughput microfluidics …
The COVID-19 pandemic has highlighted the need for human respiratory tract-based assay
platforms for efficient discovery and development of antivirals and disease-modulating …
platforms for efficient discovery and development of antivirals and disease-modulating …
3D microfluidic platform and tumor vascular mapping for evaluating anti-angiogenic RNAi-based nanomedicine
Three-dimensional (3D) visualization of tumor vasculature is a key factor in accurate
evaluation of RNA interference (RNAi)-based antiangiogenic nanomedicine, a promising …
evaluation of RNA interference (RNAi)-based antiangiogenic nanomedicine, a promising …