It is increasingly appreciated that cancer cell heterogeneity and plasticity constitute major
barriers to effective clinical treatments and long-term therapeutic efficacy. Research in the …

Relapse is common in acute myeloid leukemia (AML) and thought to be due to resistance of
underlying leukemic stem cells (LSCs) to current standard therapies, although a lack of tools …

Chemoresistance and relapse are the leading cause of AML-related deaths. Utilizing single-
cell RNA sequencing (scRNA-seq), we dissected the cellular states of bone marrow samples …

Purpose Therapy resistance is the principal obstacle to achieving cures in cancer patients
and its successful tackling requires a deep understanding of the resistance mediators …

Translation initiation is a critical facet of gene expression with important impacts that
underlie cellular responses to stresses and environmental cues. Its dysregulation in many …

Cell cycle regulation is largely abnormal in cancers. Molecular understanding and
therapeutic targeting of the aberrant cell cycle are essential. Here, we identified that an …

Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to
chemotherapy is poorly understood. In this study, we investigate the initial signaling …

AU-rich element-binding proteins (AUBPs) represent important post-transcriptional
regulators of gene expression. AUBPs can bind to the AU-rich elements present in the 3' …

Quiescent leukemic cells survive chemotherapy, with translation changes. Our data reveal
that FXR1, a protein amplified in several aggressive cancers, is elevated in quiescent and …

Aberrant function of epigenetic modifiers plays an important role not only in the progression
of cancer but also the development of drug resistance. N-alpha-acetyltransferase 40 …