Targeted therapy approaches have become the core of modern translational science and as
an intriguing field, it is the solution of the conventional drug delivery problems that were …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Numerous molecular abnormalities have been described in pulmonary arterial hypertension
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …

Although recent studies show that adipose tissue macrophages (ATMs) participate in the
inflammatory changes in obesity and contribute to insulin resistance, the properties of these …

Cardiovascular disease is the biggest killer globally and the principal contributing factor to
the pathology is atherosclerosis; a chronic, inflammatory disorder characterized by lipid and …

Since the first discovery of an inverse correlation between high‐density lipoprotein‐
cholesterol (HDL‐C) levels and coronary heart disease in the 1950s the life cycle of HDL, its …

Objective—Apolipoprotein E (apoE) exerts potent antiinflammatory effects. Here, we
investigated the effect of apoE on the functional phenotype of macrophages. Methods and …

Abstract Apolipoprotein E (apoE), a 34 kDa glycoprotein, mediates hepatic and extrahepatic
uptake of plasma lipoproteins and cholesterol efflux from lipid-laden macrophages. In …

Quantitative proteomics can be used as a screening tool for identification of differentially
expressed proteins as potential biomarkers for cancers. Candidate biomarkers from such …

Apoprotein E (apoE) is synthesized by a number of tissues including the liver, brain, adipose
tissue, and artery wall. The majority of apoE is found in the plasma associated with specific …