Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction

P Calabresi, A Mechelli, G Natale… - Cell death & …, 2023 - nature.com
Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

Dynamic shaping of cellular membranes by phospholipids and membrane-deforming proteins

S Suetsugu, S Kurisu, T Takenawa - Physiological reviews, 2014 - journals.physiology.org
All cellular compartments are separated from the external environment by a membrane,
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …

Cell membranes resist flow

Z Shi, ZT Graber, T Baumgart, HA Stone, AE Cohen - Cell, 2018 - cell.com
The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to
tension gradients. It is widely assumed that membrane flow transmits local changes in …

Role of the endolysosomal system in Parkinson's disease

DJ Vidyadhara, JE Lee… - Journal of …, 2019 - Wiley Online Library
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, affecting
1–1.5% of the total population. While progress has been made in understanding the …

α-Synuclein–regulator of exocytosis, endocytosis, or both?

J Lautenschläger, CF Kaminski, GSK Schierle - Trends in cell biology, 2017 - cell.com
α-Synuclein is known as a presynaptic protein that binds to small synaptic vesicles. Recent
studies suggest that α-synuclein is not only attracted to these tiny and therewith highly …

The physics of lipid droplet nucleation, growth and budding

AR Thiam, L Forêt - Biochimica Et Biophysica Acta (BBA)-Molecular and …, 2016 - Elsevier
Lipid droplets (LDs) are intracellular oil-in-water emulsion droplets, covered by a
phospholipid monolayer and mainly present in the cytosol. Despite their important role in …

α-Synuclein: a multifunctional player in exocytosis, endocytosis, and vesicle recycling

M Huang, B Wang, X Li, C Fu, C Wang… - Frontiers in …, 2019 - frontiersin.org
α-synuclein (α-Syn) is a presynaptic enriched protein involved in the pathogenesis of
Parkinson's disease. However, the physiological roles of α-Syn remain poorly understood …

Alpha-synuclein and lipids: the elephant in the room?

A Sarchione, A Marchand, JM Taymans… - Cells, 2021 - mdpi.com
Since the initial identification of alpha-synuclein (α-syn) at the synapse, numerous studies
demonstrated that α-syn is a key player in the etiology of Parkinson's disease (PD) and other …

Influenza A virus M2 protein: roles from ingress to egress

R Manzoor, M Igarashi, A Takada - International journal of molecular …, 2017 - mdpi.com
Influenza A virus (IAV) matrix protein 2 (M2) is among the smallest bona fide, hence
extensively studied, ion channel proteins. The M2 ion channel activity is not only essential …

Membrane elastic properties and cell function

B Pontes, Y Ayala, ACC Fonseca, LF Romao… - PloS one, 2013 - journals.plos.org
Recent studies indicate that the cell membrane, interacting with its attached cytoskeleton, is
an important regulator of cell function, exerting and responding to forces. We investigate this …