The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell
development, as well as differentiation and survival of naive T cells, and generation and …

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. One of the major
clinical challenges is adequate diagnosis and treatment of central nervous system (CNS) …

Acute leukemias (both myeloid and lymphoblastic) are a group of diseases for which each
year more successful therapies are implemented. However, in a subset of cases the overall …

Thymic Stromal Lymphopoietin (TSLP) and Interleukin-7 (IL-7) are widely studied cytokines
within distinct branches of immunology. On one hand, TSLP is crucially important for …

Abstract Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are
essential for normal lymphoid development. In their absence, severe combined …

T-cell acute lymphoblastic leukemia (T-ALL), a T-cell malignant disease that mainly affects
children, is still a medical challenge, especially for refractory patients for whom therapeutic …

Novel immunotherapies have recently led to a broadened spectrum of therapeutic options in
pediatric B-cell precursor acute lymphoblastic leukemia, even in the setting of …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy
resulting from the dysregulation of signaling pathways that control intrathymic T-cell …

Central nervous system (CNS) involvement remains a challenge in the diagnosis and
treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also …

The cytokine interleukin-7 (IL-7) and its receptor are critical for lymphoid cell development.
The loss of IL-7 signaling causes severe combined immunodeficiency, whereas gain-of …