BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …

This review is an updated and expanded version of the three prior reviews that were
published in this journal in 1997, 2003, and 2007. In the case of all approved therapeutic …

This review is an updated and expanded version of two prior reviews that were published in
this journal in 1997 and 2003. In the case of all approved agents the time frame has been …

Current research in drug discovery from medicinal plants involves a multifaceted approach
combining botanical, phytochemical, biological, and molecular techniques. Medicinal plant …

In the period 1970–2006, a total of 24 unique natural products were discovered that led to
an approved drug. We analyze these successful leads in terms of drug-like properties, and …

During the past 15 years, most large pharmaceutical companies have decreased the
screening of natural products for drug discovery in favor of synthetic compound libraries …

Terpenoids represent a diverse class of molecules that provide a wealth of opportunities to
address many human health and societal issues. The expansive array of structures and …

Fungal secondary metabolites (SMs) are an important source of medically valuable
compounds. Genome projects have revealed that fungi have many SM biosynthetic gene …

The development of new efficient therapeutics for the treatment of malaria and cancer is an
important endeavor. Over the past 15 years, much attention has been paid to the synthesis …

Covering: up to October 2005 Microorganisms and in particular actinomycetes and
microfungi are known to produce a vast number of bioactive secondary metabolites. For …