Developing sensory circuits exhibit different patterns of spontaneous activity, patterns that
are related to the construction and refinement of functional networks. During the …

Neural circuits must maintain stable function in the face of many plastic challenges,
including changes in synapse number and strength, during learning and development …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor
nervous system. We show using multielectrode array and patch-clamp recordings that …

Neuronal activity has been shown to be essential for the proper formation of neuronal
circuits, affecting developmental processes like neurogenesis, migration, programmed cell …

The neural circuits governing vital behaviors, such as respiration and locomotion, are
comprised of discrete neuronal populations residing within the brainstem and spinal cord …

Neurobiologists have long sought to understand how circuits in the nervous system are
organized to generate the precise neural outputs that underlie particular behaviours. The …

Activity-dependent plasticity of vertebrate neurons allows the brain to respond to its
environment. During brain development, both spontaneous and sensory-driven neural …

Before the onset of sensory transduction, developing neural circuits spontaneously generate
correlated activity in distinct spatial and temporal patterns. During this period of patterned …

The construction of the brain during embryonic development was thought to be largely
independent of its electrical activity. In this view, proliferation, migration and differentiation of …

Patterns of synaptic connections in the visual system are remarkably precise. These
connections dictate the receptive field properties of individual visual neurons and ultimately …