Single cell biology has revealed that solid tumors and tumor-derived cell lines typically
contain subpopulations of cancer cells that are readily distinguishable from the bulk of …

Therapeutic resistance in cancer significantly contributes to mortality, with many patients
eventually experiencing recurrence after initial treatment responses. Recent studies have …

Although metastasis is the leading cause of cancer deaths, it is quite rare at the cellular
level. Only a rare subset of cancer cells (~ 1 in 1.5 billion) can complete the entire metastatic …

The many limitations of implementing anticancer strategies under the term “precision
oncology” have been extensively discussed. While some authors propose promising future …

Simple Summary Recently, cells of large size called PGCC (Polyploid Giant Cancer Cells)
have emerged as a pillar in cancer development and progression, possibly being the “first …

Chemoresistance is a major cause of treatment failure in many cancers. However, the life
cycle of cancer cells as they respond to and survive environmental and therapeutic stress is …

Background Polyploid giant cancer cells (PGCCs) have properties of cancer stem cells
(CSCs). PGCCs with daughter cells (PDCs) undergo epithelial–mesenchymal transition and …

Our research aims to understand the adaptive—ergo potentially metastatic—responses of
prostate cancer to changing microenvironments. Emerging evidence implicates a role of the …

This study delves into the proteomic intricacies of drug-resistant cells (DRCs) within prostate
cancer, which are known for their pivotal roles in therapeutic resistance, relapse, and …

This chapter examines cancer from the lens of invasion ecology. From cancer initiation to
niche filling to tumor growth and then metastasis, the study of cancer has tight parallels to …