In the context of myocardial infarction, the burst of superoxide generated by reverse electron
transport (RET) at complex I in mitochondria is a crucial trigger for damage during …

Brain astrocytes are considered as glycolytic cell type, but these cells also produce ATP via
mitochondrial oxidative phosphorylation. Exposure of cultured primary astrocytes in a …

Mitochondrial dysfunction involving mitochondria-associated ER membrane (MAM)
dysregulation is implicated in the pathogenesis of late-onset neurodegenerative diseases …

Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to
maintain cellular homeostasis; however, mitochondria are still required for migration and …

Adenosine triphosphate (ATP) is the central energy currency of all cells. Cultured primary rat
astrocytes contain a specific cellular ATP content of 27.9±4.7 nmol/mg. During incubation in …

During hibernation, some mammals show low body temperatures (< 10° C). Tissues from
hibernators exhibit cold resistance even when the animal is not hibernating. Mice can also …

Electron cycler-mediated extracellular reduction of the water-soluble tetrazolium salt 1
(WST1) is frequently used as tool for the determination of cell viability. We have adapted this …

Abstract The glucose analogue 2-deoxyglucose (2DG) has frequently been used as a tool to
study cellular glucose uptake and to inhibit glycolysis. Exposure of primary cultured …

Astrocyte-derived pyruvate is considered to have neuroprotective functions. In order to
investigate the processes that are involved in astrocytic pyruvate release, we used primary …

The α-hydroxytropolones (αHTs) are troponoid inhibitors of hepatitis B virus (HBV)
replication that can target HBV RNase H with submicromolar efficacies. αHTs and related …