Secretory proteins are transported to the Golgi complex in vesicles that bud from the
endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for …

Vesicle trafficking from the endoplasmic reticulum (ER) is a vital cellular process in all
eukaryotes responsible for moving secretory cargoes from the ER to the Golgi apparatus. To …

To mediate the degradation of biomacromolecules, lysosomes must traffic towards cargo-
carrying vesicles for subsequent membrane fusion or fission. Mutations of the lysosomal …

In muscle and other mechanically active tissue, cell membranes are constantly injured, and
their repair depends on the injury-induced increase in cytosolic calcium. Here, we show that …

The first membrane trafficking step in the biosynthetic secretory pathway, the export of
proteins and lipids from the endoplasmic reticulum (ER), is mediated by COPII-coated …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. We screened 751
familial ALS patient whole-exome sequences and identified six mutations including p. D40G …

Lysosomes are central players in cellular catabolism, signaling, and metabolic regulation.
Cellular and environmental stresses that damage lysosomal membranes can compromise …

Secretory proteins are transported from the endoplasmic reticulum (ER) to the Golgi complex
in carriers that are formed by the concerted activities of cytoplasmic proteins in the coat …

A full mechanistic understanding of how secretory cargo proteins are exported from the
endoplasmic reticulum for passage through the early secretory pathway is essential for us to …

Apoptosis linked Gene-2 (ALG-2) is a multifunctional intracellular Ca2+ sensor and the
archetypal member of the penta-EF hand protein family. ALG-2 functions in the repair of …