The median survival of glioblastoma patients is∼ 12 months. However, 3–5% of the patients
survives for more than 3 years and are referred to as long-term survivors. The clinical and …

Malignant gliomas such as glioblastoma multiforme (GBM) present some of the greatest
challenges in the management of cancer patients worldwide, despite notable recent …

A recent study reported on mutations in the active site of the isocitrate dehydrogenase
(IDH1) gene in 12% of glioblastomas. All mutations detected resulted in an amino acid …

Gangliogliomas represent the most frequent tumor entity in young patients suffering from
chronic focal epilepsies. In a series of 326 gangliogliomas collected from the University of …

Meningiomas are mostly benign, slow-growing tumors of the CNS that originate from
arachnoidal cap cells. While monosomy 22 is the most frequent genetic abnormality found in …

Over the past 5 to 10 years, important advances were made in the understanding of
meningioma biology. Progress in molecular genetics probably represents the most important …

The recognition of molecular subsets among glioblastomas has raised the question whether
distinct mutations in glioblastoma-associated genes may serve as prognostic markers. The …

Glioblastoma is the commonest primary brain tumor, as well as the deadliest. Malignant
gliomas such as glioblastoma multiforme (GBM) present some of the greatest challenges in …

In the adult population, glioblastoma multiforme is one of the most common primary brain
tumors encountered. Unfortunately, this highly malignant tumor represents over 50% of all …

Prognostic value of histological grading of oligodendroglial tumors is controversial and
interobserver reproducibility in grading of these tumors is unknown. Seven …