Are mast cells MASTers in cancer?

G Varricchi, MR Galdiero, S Loffredo… - Frontiers in …, 2017 - frontiersin.org
Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast
cells form a heterogeneous population of immune cells with differences in their ultra …

The role of mast cells in molding the tumor microenvironment

A Rigoni, MP Colombo, C Pucillo - Cancer microenvironment, 2015 - Springer
Mast cells (MCs) are granulocytic immune cells that reside in tissues exposed to the external
environment. MCs are best known for their activity in allergic reactions, but they have been …

Comprehensive analysis of PD-L1 expression, immune infiltrates, and m6A RNA methylation regulators in esophageal squamous cell carcinoma

W Guo, F Tan, Q Huai, Z Wang, F Shao… - Frontiers in …, 2021 - frontiersin.org
Background Esophageal squamous cell carcinoma (ESCC) is one of the most common
cancer types and represents a threat to global public health. N6-Methyladenosine (m6A) …

Role of mast cells activation in the tumor immune microenvironment and immunotherapy of cancers

X Guo, M Sun, P Yang, X Meng, R Liu - European Journal of Pharmacology, 2023 - Elsevier
The mast cell is an important cellular component that plays a crucial role in the crosstalk
between innate and adaptive immune responses within the tumor microenvironment (TME) …

Innate immune cells in the esophageal tumor microenvironment

K Cui, S Hu, X Mei, M Cheng - Frontiers in Immunology, 2021 - frontiersin.org
Esophageal cancer (EC) is one of the most common mucosa-associated tumors, and is
characterized by aggressiveness, poor prognosis, and unfavorable patient survival rates. As …

Mast cell-targeted strategies in cancer therapy

M Ammendola, R Sacco, G Sammarco… - Transfusion Medicine …, 2016 - karger.com
Mast cells (MCs) are cells that originate in the bone marrow from pluripotent CD34+
hematopoietic stem cells. Precursors of MCs migrate through the circulation to their target …

High infiltration of mast cells positive to tryptase predicts worse outcome following resection of colorectal liver metastases

S Suzuki, Y Ichikawa, K Nakagawa, T Kumamoto… - BMC cancer, 2015 - Springer
Background Accumulation of tumor-infiltrating mast cells (MCs) predicts poor survival in
several cancers after resection. However, its effect on the prognosis of patients with …

Dissecting the inflammatory tumor microenvironment of esophageal adenocarcinoma: mast cells and natural killer cells are favorable prognostic factors and …

AC dos Santos Cunha, AG Simon, T Zander… - Journal of Cancer …, 2023 - Springer
Purpose Esophageal adenocarcinoma (EAC) remains a challenging and lethal cancer
entity. A promising target for new therapeutic approaches, as demonstrated by the success …

Oxidative stress genes in patients with esophageal squamous cell carcinoma: construction of a novel prognostic signature and characterization of tumor …

W Liu, HS Yang, SY Zheng, HH Luo, YF Feng… - BMC bioinformatics, 2022 - Springer
Background Oxidative stress plays an important role in the progression of various types of
tumors. However, its role in esophageal squamous cell carcinoma (ESCC) has seldom been …

Mast cell density in metastatic renal cell carcinoma: Association with prognosis and tumour‐infiltrating lymphocytes

J Yao, W Xi, X Chen, Y Xiong, Y Zhu… - Scandinavian …, 2021 - Wiley Online Library
Tumour‐infiltrating mast cells (TIMs) have been reported to play functional roles in the
tumour microenvironment. However, controversial evidences exist regarding their impact in …