A reflection of our ultimate understanding of a complex system is our ability to control its
behavior. Typically, control has multiple prerequisites: it requires an accurate map of the …

Understanding complex biological systems requires extensive support from software tools.
Such tools are needed at each step of a systems biology computational workflow, which …

A quantitative description of a complex system is inherently limited by our ability to estimate
the system's internal state from experimentally accessible outputs. Although the …

Nature discovered feedback long ago. It created feedback mechanisms and exploited them
at all levels, that are central to homeostasis and life. As a technology, control dates back at …

The protein–protein interaction (PPI) network is crucial for cellular information processing
and decision-making. With suitable inputs, PPI networks drive the cells to diverse functional …

As the title suggests, the subject of this book is the emergence of complexity and the mind,
focusing on the role of top-down causation. The aim is to engage with the complexity of the …

Gene expression plays a central role in the orchestration of cellular processes. The use of
inducible promoters to change the expression level of a gene from its physiological level has …

Background The human neuroblastoma cell line, SH-SY5Y, is a commonly used cell line in
studies related to neurotoxicity, oxidative stress, and neurodegenerative diseases. Although …

Both bottom-up and top-down causation occur in the hierarchy of structure and causation. A
key feature is multiple realizability of higher level functions, and consequent existence of …

Signaling pathways control cell fate decisions that ultimately determine the behavior of
cancer cells. Therefore, the dynamics of pathway activity may contain prognostically relevant …