The original paradigm of classical-also referred to as canonical-cellular signal transduction
of heterotrimeric G proteins (G protein) is defined by a hierarchical, orthograde interaction of …

Under physiological conditions microglia, the immune sentinels of the brain, constantly
monitor their microenvironment. In the case of danger, damage or cell/tissue …

Store-operated calcium entry (SOCE) is an important pathway for calcium signaling that
regulates calcium influx across the plasma membrane upon the depletion of calcium stores …

Recent findings suggest an important role for the dysregulation of stromal interaction
molecule (STIM) proteins, activators of store-operated Ca2+ channels, and the prolonged …

Immune cells-enhanced immunotherapy exhibits unprecedented overall survival-
prolongation even curable in some cancer patients. Although so, most of the patients show …

Persistent challenges complicating the treatment of breast cancer remain, despite some
recent undeniable successes. Sufficient evidence currently exists demonstrating the crucial …

Microglia, the unique and motile immune cells of the central nervous system (CNS), function
as a security guard in maintaining CNS homeostasis, primarily through calcium signaling …

Microglia play a critical role in maintaining brain homeostasis but become dysregulated in
neurodegenerative diseases. Regulator of G-protein Signaling 10 (RGS10), one of the most …

Glia are essential neurons of the immune system in the central nervous system. The effective
mission of glia depends on their activation, release of cytokines, and oxidative cleaning of …

Regulator of G-protein signaling 10 (RGS10), a key homeostatic regulator of immune cells,
has been implicated in multiple diseases associated with aging and chronic inflammation …