Synaptic neurexin complexes: a molecular code for the logic of neural circuits
TC Südhof - Cell, 2017 - cell.com
Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …
information, thereby connecting neurons into millions of overlapping and interdigitated …
Neurexins: molecular codes for shaping neuronal synapses
AM Gomez, L Traunmüller, P Scheiffele - Nature Reviews …, 2021 - nature.com
The function of neuronal circuits relies on the properties of individual neuronal cells and
their synapses. We propose that a substantial degree of synapse formation and function is …
their synapses. We propose that a substantial degree of synapse formation and function is …
Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders
R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …
complex genetic architectures but overlapping behavioral phenotypes, which suggests …
Expansion of the eukaryotic proteome by alternative splicing
TW Nilsen, BR Graveley - Nature, 2010 - nature.com
The collection of components required to carry out the intricate processes involved in
generating and maintaining a living, breathing and, sometimes, thinking organism is …
generating and maintaining a living, breathing and, sometimes, thinking organism is …
Modeling autism by SHANK gene mutations in mice
Y Jiang, MD Ehlers - Neuron, 2013 - cell.com
Shank family proteins (Shank1, Shank2, and Shank3) are synaptic scaffolding proteins that
organize an extensive protein complex at the postsynaptic density (PSD) of excitatory …
organize an extensive protein complex at the postsynaptic density (PSD) of excitatory …
Neuroligins and neurexins link synaptic function to cognitive disease
TC Südhof - Nature, 2008 - nature.com
The brain processes information by transmitting signals at synapses, which connect neurons
into vast networks of communicating cells. In these networks, synapses not only transmit …
into vast networks of communicating cells. In these networks, synapses not only transmit …
[HTML][HTML] Astrocytes assemble thalamocortical synapses by bridging NRX1α and NL1 via hevin
SK Singh, JA Stogsdill, NS Pulimood, H Dingsdale… - Cell, 2016 - cell.com
Proper establishment of synapses is critical for constructing functional circuits. Interactions
between presynaptic neurexins and postsynaptic neuroligins coordinate the formation of …
between presynaptic neurexins and postsynaptic neuroligins coordinate the formation of …
Pleiotropy and cross-disorder genetics among psychiatric disorders
Genome-wide analyses of common and rare genetic variations have documented the
heritability of major psychiatric disorders, established their highly polygenic genetic …
heritability of major psychiatric disorders, established their highly polygenic genetic …
Advances in autism genetics: on the threshold of a new neurobiology
BS Abrahams, DH Geschwind - Nature reviews genetics, 2008 - nature.com
Autism is a heterogeneous syndrome defined by impairments in three core domains: social
interaction, language and range of interests. Recent work has led to the identification of …
interaction, language and range of interests. Recent work has led to the identification of …
RNA processing and its regulation: global insights into biological networks
DD Licatalosi, RB Darnell - Nature Reviews Genetics, 2010 - nature.com
In recent years views of eukaryotic gene expression have been transformed by the finding
that enormous diversity can be generated at the RNA level. Advances in technologies for …
that enormous diversity can be generated at the RNA level. Advances in technologies for …