A review on nanotechnology: Properties, applications, and mechanistic insights of cellular uptake mechanisms
Nanotechnology is a relatively new field of science and technology that studies tiny objects
(0.1–100 nm). Due to various positive attributes displayed by the biogenic synthesis of …
(0.1–100 nm). Due to various positive attributes displayed by the biogenic synthesis of …
Self-assembling, supramolecular chemistry and pharmacology of amphotericin B: Poly-aggregates, oligomers and monomers
R Fernández-García, JC Muñoz-García… - Journal of Controlled …, 2022 - Elsevier
Antifungal drugs such as amphotericin B (AmB) interact with lipids and phospholipids
located on fungal cell membranes to disrupt them and create pores, leading to cell apoptosis …
located on fungal cell membranes to disrupt them and create pores, leading to cell apoptosis …
Effect of aggregation state on the toxicity of different amphotericin B preparations
The aim of this work was to study the effect of aggregation of amphotericin B (AMB) in their
toxicity. The aggregation of AMB depends on different formulation factors such as pH and …
toxicity. The aggregation of AMB depends on different formulation factors such as pH and …
Biomimetically engineered Amphotericin B nano-aggregates circumvent toxicity constraints and treat systemic fungal infection in experimental animals
Biomimetic synthesis of nanoparticles offers a convenient and bio friendly approach to
fabricate complex structures with sub-nanometer precision from simple precursor …
fabricate complex structures with sub-nanometer precision from simple precursor …
Hemolytic and pharmacokinetic studies of liposomal and particulate amphotericin B formulations
DR Serrano, L Hernández, L Fleire… - International journal of …, 2013 - Elsevier
Amphotericin B (AmB) is a very effective antifungal and antiparasitic drug with a narrow
therapeutic window. To improve its efficacy/toxicity balance, new controlled release …
therapeutic window. To improve its efficacy/toxicity balance, new controlled release …
Super aggregated form of Amphotericin B: a novel way to increase its therapeutic index
Amphotericin B (AmB)-deoxycholate micellar formulation, Fungizone®, is the drug of choice
for the treatment of unidentified mycotic infections. However, it usage has been marred by …
for the treatment of unidentified mycotic infections. However, it usage has been marred by …
Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans
In the present study, we developed a self-assembled biodegradable polyglutamic acid
(PGA)-based formulation of amphotericin B (AmB) and evaluated its in vitro antifungal …
(PGA)-based formulation of amphotericin B (AmB) and evaluated its in vitro antifungal …
Amphotericin B nano-assemblies circumvent intrinsic toxicity and ensure superior protection in experimental visceral leishmaniasis with feeble toxic manifestation
In spite of its high effectiveness in the treatment of both leishmaniasis as well as a range of
fungal infections, the free form of the polyene antibiotic amphotericin B (AmB) does not …
fungal infections, the free form of the polyene antibiotic amphotericin B (AmB) does not …
Development of dextrin-amphotericin B formulations for the treatment of Leishmaniasis
R Silva-Carvalho, J Fidalgo, KR Melo… - International journal of …, 2020 - Elsevier
The most effective medicines available for the treatment of leishmaniasis, a life-threatening
disease, exhibit serious toxicological issues. To achieve better therapeutic efficiency while …
disease, exhibit serious toxicological issues. To achieve better therapeutic efficiency while …
Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats
Oral delivery of amphotericin B (AmpB) is desirable because it provides a more patient-
friendly mode of administration compared to the current delivery approach akin with the …
friendly mode of administration compared to the current delivery approach akin with the …