Aging is typified by a gradual loss of physiological fitness and accumulation of cellular
damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging …

In the last few decades, many pathogenic or likely pathogenic genetic mutations in over
hundred different genes have been described for non-ischemic, genetic cardiomyopathies …

Cardiomyocytes (CM) placed on microelectrode array (MEA) were simultaneously probed
with cantilever from atomic force microscope (AFM) system. This electric/nanomechanical …

Aging is associated with a progressive and functional decline of all tissues and a striking
increase in many “age-related diseases”. Although aging has long been considered an …

Cardiomyocyte contraction and relaxation are important parameters of cardiac function
altered in many heart pathologies. Biosensing of these parameters represents an important …

Stem cells have huge potential in many therapeutic areas. With conventional cell culture
methods, however, it is difficult to achieve in vivo-like microenvironments in which a number …

Background: Sarcoplasmic reticulum Ca2+ leak and post-translational modifications under
stress have been implicated in catecholaminergic polymorphic ventricular tachycardia …

The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain
normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular …

Genetic cardiac diseases are major causes of morbidity and mortality. Although animal
models have been created to provide some useful insights into the pathogenesis of genetic …

Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced
pluripotent stem cells (iPSCs), with their ability of indefinite self‐renewal and capability to …