Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …

The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …

Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for
the proper function of major organs including the brain, the respiratory system and the …

A finely regulated system of airway epithelial development governs the differentiation of
motile ciliated cells of the human respiratory tract, conferring the body's mucociliary …

Ependymoma is a heterogeneous entity of central nervous system tumors with well-
established molecular groups. Here, we apply single-cell RNA sequencing to analyze …

Cigarette smoke first interacts with the lung through the cellularly diverse airway epithelium
and goes on to drive development of most chronic lung diseases. Here, through single cell …

The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …

The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …

The p53 transcription factor confers its potent tumor suppressor functions primarily through
the regulation of a large network of target genes. The recent explosion of next generation …