Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity
M Cooke, MG Kazanietz - Science Signaling, 2022 - science.org
Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …
extracellular stimuli and channels intracellular signals that affect mammalian cell …
[HTML][HTML] Regulatory mechanisms of miR-145 expression and the importance of its function in cancer metastasis
MicroRNAs are post-transcriptional mediators of gene expression and regulation, which play
influential roles in tumorigenesis and cancer metastasis. The expression of tumor …
influential roles in tumorigenesis and cancer metastasis. The expression of tumor …
[HTML][HTML] Regulation of Hippo/YAP signaling and Esophageal Squamous Carcinoma progression by an E3 ubiquitin ligase PARK2
X Zhou, Y Li, W Wang, S Wang, J Hou, A Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Objective: Esophageal squamous cell carcinoma (ESCC) is one of the most commonly
diagnosed cancer types in China. Recent genomic sequencing analysis indicated the over …
diagnosed cancer types in China. Recent genomic sequencing analysis indicated the over …
Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and …
Y Chen, D Wang, H Peng, X Chen, X Han, J Yu… - Molecular Cancer, 2019 - Springer
Background Esophageal squamous cell carcinoma (ESCC) is one of the most lethal
malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to …
malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to …
Application of CRISPR/Cas9 gene editing technique in the study of cancer treatment
C Jiang, L Meng, B Yang, X Luo - Clinical genetics, 2020 - Wiley Online Library
In recent years, gene editing, especially that using clustered regularly interspaced short
palindromic repeat (CRISPR)/Cas9, has made great progress in the field of gene function …
palindromic repeat (CRISPR)/Cas9, has made great progress in the field of gene function …
Circular RNAs with protein-coding ability in oncogenesis
J Cheng, G Li, W Wang, DB Stovall, G Sui… - Biochimica et Biophysica …, 2023 - Elsevier
As ubiquitously expressed transcripts in eukaryotes, circular RNAs (circRNAs) are covalently
closed and lack a 5′-cap and 3′-polyadenylation (poly (A)) tail. Initially, circRNAs were …
closed and lack a 5′-cap and 3′-polyadenylation (poly (A)) tail. Initially, circRNAs were …
Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations
C Yan, M Zhu, Y Ding, M Yang, M Wang, G Li, C Ren… - Gut, 2020 - gut.bmj.com
Objective Although a subset of genetic loci have been associated with gastric cancer (GC)
risk, the underlying mechanisms are largely unknown. We aimed to identify new …
risk, the underlying mechanisms are largely unknown. We aimed to identify new …
The plasma peptides of ovarian cancer
J Dufresne, P Bowden, T Thavarajah… - Clinical proteomics, 2018 - Springer
Background It may be possible to discover new diagnostic or therapeutic peptides or
proteins from blood plasma by using liquid chromatography and tandem mass spectrometry …
proteins from blood plasma by using liquid chromatography and tandem mass spectrometry …
LOTUS: A single-and multitask machine learning algorithm for the prediction of cancer driver genes
O Collier, V Stoven, JP Vert - PLoS computational biology, 2019 - journals.plos.org
Cancer driver genes, ie, oncogenes and tumor suppressor genes, are involved in the
acquisition of important functions in tumors, providing a selective growth advantage …
acquisition of important functions in tumors, providing a selective growth advantage …
[HTML][HTML] SHARPIN inhibits esophageal squamous cell carcinoma progression by modulating hippo signaling
A Zhang, W Wang, Z Chen, D Pang, X Zhou, K Lu… - Neoplasia, 2020 - Elsevier
Esophageal cancer is one of the leading malignancies worldwide, while around sixty
percent of newly diagnosed cases are in China. In recent years, genome-wide sequencing …
percent of newly diagnosed cases are in China. In recent years, genome-wide sequencing …