Heart failure is a worldwide pandemic influencing 26 million individuals worldwide and is
expanding. Imbalanced redox homeostasis in cardiac cells alters the structure and function …

The cytoprotective effects of the heme oxygenase (HO) pathway are widely acknowledged.
These effects are mainly mediated by degradation of free, pro-oxidant heme and the …

Propofol is one of the most extensively used intravenous anaesthetic agents, which has
been found to improve the surgical intervention outcome of several types of cancer …

Propofol offers important protective effects in ischemia/reperfusion-induced cardiomyocyte
injury, but its specific mechanisms in doxorubicin (DOX)-induced cardiotoxicity have not …

Macrophages are key immune system cells involved in inflammatory processes. Classically
activated (M1) macrophages are characterized by strong antimicrobicidal properties …

Myocardial ischemia/reperfusion injury (I/RI) frequently incurs in acute myocardial infarction
with high morbidity and mortality worldwide and is characterized with cardiomyocyte …

Objective: The objective of this study was to investigate the effects of trimetazidine (TMZ) and
coenzyme Q10 (CoQ10) on cisplatin-induced cardiotoxicity in rat cardiomyocytes. Methods …

We have been developing CRISPR-directed gene editing as an augmentative therapy for
the treatment of non-small cell lung carcinoma (NSCLC) by genetic disruption of Nuclear …

Oxidative stress resulting from decreased antioxidant protection and increased reactive
oxygen and nitrogen species (RONS) production may contribute to muscle mass loss and …

Oleuropein, one of the main polyphenolic constituents of olive, is cardioprotective against
ischemia reperfusion injury (IRI). We aimed to assess the cardioprotection afforded by acute …