A state of oxidative stress (OS) and the presence of reactive oxygen species (ROS) in the
male reproductive tract are strongly correlated with infertility. While physiological levels of …

Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient
cells, but their efficacy in BRCA-deficient patients is limited by drug resistance. Here, we …

Impacting the lives of millions throughout the globe, cancer is the world's leading cause of
death. In cancer treatment and prognosis, a number of anticancer medicines have been …

Abstract Rationale: Small 225 Ac-labeled prostate-specific membrane antigen (PSMA)-
targeted radioconjugates have been described for targeted alpha therapy of metastatic …

DNA glycosylases are involved in the base excision repair pathway, and all mammals
express multiple DNA glycosylases to maintain genome stability. However, the simultaneous …

Background Our previous study has demonstrated that NAD (P) H: quinone oxidoreductase
1 (NQO1) is significantly upregulated in human liver cancer where it potentiates the …

Mutations in SPOP, the gene most frequently point-mutated in primary prostate cancer, are
associated with a high degree of genomic instability and deficiency in homologous …

Prostatic diseases are a common health problem among males in Western countries, and
include chronic prostatic diseases, which have an unclear pathogenesis and few treatment …

DNA repair enzymes are responsible for the repair of DNA lesions and are important
disease biomarkers. Herein, we construct a target-triggered DNAzyme motor for …

Abstract cAMP response element-binding (CREB) protein is a cellular transcription factor
that mediates responses to different physiological and pathological signals. Using a model …