Due to its channel-like properties, the peripheral-type benzodiazepine receptor (PBR) has
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …

The “holy grail” of cancer therapy is to identify and exploit genetic elements and signal
transduction pathways capable of selectively destroying tumor cells without eliciting harmful …

Background and Purpose Ashwagandha is a popular Ayurvedic herb used in Indian
traditional home medicine. It has been assigned a variety of health-promoting effects of …

Abstract Interleukin-22 (IL-22) is an IL-10 family cytokine produced by T cells and innate
lymphoid cells. The IL-22 signaling pathway orchestrates mucosal immune defense and …

First identified almost two decades ago as a novel gene differentially expressed in human
melanoma cells induced to terminally differentiate, MDA-7/IL-24 has since shown great …

“Differentiation therapy” provides a unique and potentially effective, less toxic treatment
paradigm for cancer. Moreover, combining “differentiation therapy” with molecular …

Apoptosis and autophagy play seminal roles in maintaining organ homeostasis. Apoptosis
represents canonical type I programmed cell death. Autophagy is viewed as pro-survival …

Melanoma differentiation associated gene-7 (mda-7) was cloned using subtraction
hybridization from terminally differentiated human melanoma cells. Based on structural and …

A noteworthy aspect of melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-
24) as a cancer therapeutic is its ability to selectively kill cancer cells without harming normal …

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique
member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with …