Because of our limited knowledge of the functional role of the thalamostriatal system, this
massive network is often ignored in models of the pathophysiology of brain disorders of …

Of all the truncothalamic nuclei, the centromedian-parafascicular nuclei complex (CM-Pf) is
the largest and is considered the prototypic thalamic projection system. Located among the …

Movement suppression in Parkinson's disease (PD) is thought to arise from increased
efficacy of the indirect pathway basal ganglia circuit, relative to the direct pathway. However …

The neurosurgical treatment of movement disorders, primarily via deep brain stimulation
(DBS), is a rapidly expanding and evolving field. Although conventional targets including the …

The parafascicular nucleus (Pf) of the thalamus provides major projections to the basal
ganglia, a set of subcortical nuclei involved in action initiation. Here, we show that Pf …

Although we have gained significant knowledge in the anatomy and microcircuitry of the
thalamostriatal system over the last decades, the exact function (s) of these complex …

The intralaminar thalamus, in particular the centromedian-parafascicular complex, forms a
strategic node between ascending information from the spinal cord and brainstem and …

Background The zona incerta (ZI) is involved in mediating survival behaviors and is
connected to a wide range of cortical and subcortical structures, including key basal ganglia …

Deep brain stimulation (DBS) for secondary (acquired, combined) dystonia does not reach
the high degree of efficacy achieved in primary (genetic, isolated) dystonia. We hypothesize …

The basal ganglia (BG) are a group of subcortical structures involved in diverse functions,
such as motor, cognition and emotion. However, the BG do not control these functions …