Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and …
A series of around eight novel chalcone based coumarin derivatives (23a-h) was designed,
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …
Thiazole-pyrazoline hybrids as potential antimicrobial agent: Synthesis, biological evaluation, molecular docking, DFT studies and POM analysis
In this study, an efficient synthesis of new thiazole-pyrazoline hybrids was investigated and
hybrids were screened for their antimicrobial activities against four species of pathogenic …
hybrids were screened for their antimicrobial activities against four species of pathogenic …
Discovery of novel coumarin-schiff base hybrids as potential acetylcholinesterase inhibitors: design, synthesis, enzyme inhibition, and computational studies
AH Hasan, FA Abdulrahman, AJ Obaidullah… - Pharmaceuticals, 2023 - mdpi.com
To discover anti-acetylcholinesterase agents for the treatment of Alzheimer's disease (AD), a
series of novel Schiff base-coumarin hybrids was rationally designed, synthesized …
series of novel Schiff base-coumarin hybrids was rationally designed, synthesized …
Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids
The major enzyme responsible for the hydrolytic breakdown of the neurotransmitter
acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors …
acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors …
Design, synthesis, biological activity, molecular docking, and molecular dynamics of novel benzimidazole derivatives as potential AChE/MAO‐B dual inhibitors
To develop new acetylcholinesterase (AChE)–monoamine oxidase‐B (MAO‐B) dual
inhibitors against Alzheimer's disease, the benzimidazole ring, which has a propargyl side …
inhibitors against Alzheimer's disease, the benzimidazole ring, which has a propargyl side …
Synthesis, biological evaluation and molecular modeling studies of modulated benzyloxychalcones as potential acetylcholinesterase inhibitors
Acetylcholinesterase inhibitors (AChEIs) have become a significant target in the search for
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
Design and discovery of anthranilamide derivatives as a potential treatment for neurodegenerative disorders via targeting cholinesterases and monoamine oxidases
Neurodegenerative diseases with progressive cellular loss of the central nervous system
and elusive disease etiology provide a continuous impetus to explore drug discovery …
and elusive disease etiology provide a continuous impetus to explore drug discovery …
Coumarin–azasugar–benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth
ICV Holmgard, A González-Bakker, E Poeta… - Organic & …, 2024 - pubs.rsc.org
We have applied the copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction to
prepare a library of ten coumarin–azasugar–benzyl conjugates and two phthalimide …
prepare a library of ten coumarin–azasugar–benzyl conjugates and two phthalimide …
Design and synthesis of novel chalcone derivatives and evaluation of their inhibitory activities against acetylcholinesterase
According to the cholinergic hypothesis, an increase in the acetylcholine level in Alzheimer's
disease patients relatively slows down the symptoms of the disease. The most commonly …
disease patients relatively slows down the symptoms of the disease. The most commonly …
Benzyloxychalcone Hybrids as Prospective Acetylcholinesterase Inhibitors against Alzheimer's Disease: Rational Design, Synthesis, In Silico ADMET Prediction …
HM Al-Maqtari, AH Hasan, M Suleiman… - ACS …, 2024 - ACS Publications
Acetylcholinesterase inhibitors (AChEIs) are crucial therapeutic targets for both the early and
severe stages of Alzheimer's disease (AD). Chalcones and their chromone-based …
severe stages of Alzheimer's disease (AD). Chalcones and their chromone-based …