Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

Gene expression profiles of more than 10,000 individual microglial cells isolated from cortex
and hippocampus of male and female App NL-GF mice over time demonstrate that …

Accumulation of damaged mitochondria is a hallmark of aging and age-related
neurodegeneration, including Alzheimer's disease (AD). The molecular mechanisms of …

Background Evidence on preventing Alzheimer's disease (AD) is challenging to interpret
due to varying study designs with heterogeneous endpoints and credibility. We completed a …

Recent critical commentaries unfavorably compare deep learning (DL) with standard
machine learning (SML) approaches for brain imaging data analysis. However, their …

The presence, magnitude, and significance of sex differences in the human brain are hotly
debated topics in the scientific community and popular media. This debate is largely fueled …

Protein S-nitros (yl) ation (SNO) is a posttranslational modification involved in diverse
processes in health and disease and can contribute to synaptic damage in Alzheimer's …

Sex differences in the human brain are of interest for many reasons: for example, there are
sex differences in the observed prevalence of psychiatric disorders and in some …

Abstract Subjective Cognitive Decline (SCD) in older adults has been identified as a risk
factor for dementia, although the literature is inconsistent, and it is unclear which factors …