• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received
special attention because of its function in the development and progression of …

Inflammatory activation is increasingly recognized as a nonconventional risk factor for
arrhythmias, and experimental studies provided robust evidence that this association is …

Arrhythmogenic cardiomyopathy (ACM) is a heart muscle disease characterized by
prominent “non-ischemic” myocardial scarring predisposing to ventricular electrical …

Background: There is a paucity of data regarding the phenotype of dilated cardiomyopathy
(DCM) gene variants in the general population. We aimed to determine the frequency and …

Over recent years, preclinical and clinical evidence has implicated myocardial inflammation
(M-Infl) in the pathophysiology and phenotypes of traditionally genetic cardiomyopathies. M …

The authors present a clinical report focused on the overlap between myocarditis and
genetic cardiomyopathies of the dilated and arrhythmogenic spectrum. Our cohort was …

Myocarditis is clinically characterized by chest pain, arrhythmias, and heart failure, and
treatment is often supportive. Mutations in DSP, a gene encoding the desmosomal protein …

Arrhythmogenic cardiomyopathy (ACM) is a genetically determined myocardial disease,
characterized by myocytes necrosis with fibrofatty substitution and ventricular arrhythmias …

Background Inherited cardiomyopathies present with broad variation of phenotype. Data are
limited regarding genetic screening strategies and outcomes associated with predicted …