Germinal centres and B cell lymphomagenesis
K Basso, R Dalla-Favera - Nature Reviews Immunology, 2015 - nature.com
Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …
Next-generation sequencing in the clinic: promises and challenges
The advent of next generation sequencing (NGS) technologies has revolutionized the field
of genomics, enabling fast and cost-effective generation of genome-scale sequence data …
of genomics, enabling fast and cost-effective generation of genome-scale sequence data …
Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is
a clinically and genetically heterogeneous disease that is further classified into …
a clinically and genetically heterogeneous disease that is further classified into …
Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing
Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous cancer composed of
at least 2 molecular subtypes that differ in gene expression and distribution of mutations …
at least 2 molecular subtypes that differ in gene expression and distribution of mutations …
Germinal center‐derived lymphomas: The darkest side of humoral immunity
C Mlynarczyk, L Fontán, A Melnick - Immunological reviews, 2019 - Wiley Online Library
One of the unusual features of germinal center (GC) B cells is that they manifest many
hallmarks of cancer cells. Accordingly, most B‐cell neoplasms originate from the GC …
hallmarks of cancer cells. Accordingly, most B‐cell neoplasms originate from the GC …
Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas
K Georgiou, L Chen, M Berglund, W Ren… - Blood, The Journal …, 2016 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive types of
B-cell lymphoma. Deregulation of proto-oncogene expression after a translocation, most …
B-cell lymphoma. Deregulation of proto-oncogene expression after a translocation, most …
[HTML][HTML] Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-
cells. Prognosis is strongly associated with molecular subgroup, although the driver …
cells. Prognosis is strongly associated with molecular subgroup, although the driver …
Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas
G Vasmatzis, SH Johnson, RA Knudson… - Blood, The Journal …, 2012 - ashpublications.org
Peripheral T-cell lymphomas (PTCLs) are aggressive malignancies of mature T lymphocytes
with 5-year overall survival rates of only∼ 35%. Improvement in outcomes has been stymied …
with 5-year overall survival rates of only∼ 35%. Improvement in outcomes has been stymied …
Anaplastic large cell lymphomas: ALK positive, ALK negative, and primary cutaneous
X Xing, AL Feldman - Advances in anatomic pathology, 2015 - journals.lww.com
Anaplastic large cell lymphomas (ALCLs) comprise a group of CD30-positive non-Hodgkin
lymphomas that generally are of T-cell origin and share common morphologic and …
lymphomas that generally are of T-cell origin and share common morphologic and …
Recurrent genomic rearrangements in primary testicular lymphoma
Primary testicular diffuse large B cell lymphoma (PTL) is an aggressive malignancy that
occurs in the immune‐privileged anatomical site of the testis. We have previously shown that …
occurs in the immune‐privileged anatomical site of the testis. We have previously shown that …