Inflammatory cytokines and chemokines as therapeutic targets in heart failure

A Hanna, NG Frangogiannis - Cardiovascular Drugs and Therapy, 2020 - Springer
Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …

Targeting the NLRP3 inflammasome in severe COVID-19

TL Freeman, TH Swartz - Frontiers in immunology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies

Q Guo, Y Wang, D Xu, J Nossent, NJ Pavlos, J Xu - Bone research, 2018 - nature.com
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects
the lining of the synovial joints and is associated with progressive disability, premature …

The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases

S Toldo, A Abbate - Nature Reviews Cardiology, 2024 - nature.com
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …

Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications

BR England, GM Thiele, DR Anderson, TR Mikuls - Bmj, 2018 - bmj.com
Rheumatoid arthritis is a systemic autoimmune disease characterized by excess morbidity
and mortality from cardiovascular disease. Mechanisms linking rheumatoid arthritis and …

Assessment of myocardial mechanics using speckle tracking echocardiography: fundamentals and clinical applications

H Geyer, G Caracciolo, H Abe, S Wilansky… - Journal of the American …, 2010 - Elsevier
The authors summarize the recent developments in speckle-tracking echocardiography
(STE), a relatively new technique that can be used in conjunction with two-dimensional or …

Cardiovascular effects of approved drugs for rheumatoid arthritis

F Atzeni, J Rodríguez-Carrio, CD Popa… - Nature Reviews …, 2021 - nature.com
The risk of cardiovascular disease is increased in patients with rheumatoid arthritis
compared with the general population owing to the influence of traditional and non …

[HTML][HTML] Redox-related biomarkers in human cardiovascular disease-classical footprints and beyond

A Daiber, O Hahad, I Andreadou, S Steven, S Daub… - Redox Biology, 2021 - Elsevier
Global epidemiological studies show that chronic non-communicable diseases such as
atherosclerosis and metabolic disorders represent the leading cause of premature mortality …

Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies

G Cavalli, CA Dinarello - Rheumatology, 2015 - academic.oup.com
The inflammatory cytokines IL-1α and IL-1β orchestrate local and systemic inflammatory
responses underlying a broad spectrum of diseases. Three agents for reducing IL-1 …

[HTML][HTML] Interleukin-1 (IL-1) and the inflammasome in cancer

V Pretre, D Papadopoulos, J Regard, M Pelletier… - Cytokine, 2022 - Elsevier
Numerous preclinical and clinical studies have demonstrated the significant contribution of
inflammation to the development and progression of various types of cancer. Inflammation in …