The importance of synthetic drugs for type 2 diabetes drug discovery
Introduction: Type 2 diabetes mellitus (T2DM) is a major metabolic, multi-causal and
heterogeneous disorder which causes significant morbidity and mortality with considerable …
heterogeneous disorder which causes significant morbidity and mortality with considerable …
[HTML][HTML] A review on the medicinal chemistry of sodium glucose co-transporter 2 inhibitors (SGLT2-I): Update from 2010 to present
Diabetes mellitus (DM) is one of the leading causes of death by World Health Organization
in 2019 and is considered a significant cause of other diseases including heart attack …
in 2019 and is considered a significant cause of other diseases including heart attack …
In silico molecular investigations of pyridine N-Oxide compounds as potential inhibitors of SARS-CoV-2: 3D QSAR, molecular docking modeling, and ADMET …
The new coronavirus SARS-CoV-2 virus is causing a severe pneumonia in human,
provoking the serious outbreak epidemic CoV-2. Since its appearance in Wuhan, China on …
provoking the serious outbreak epidemic CoV-2. Since its appearance in Wuhan, China on …
In silico research on new sulfonamide derivatives as BRD4 inhibitors targeting acute myeloid leukemia using various computational techniques including 3D-QSAR …
E Belghalia, M Ouabane, S El Bahi… - Journal of …, 2024 - Taylor & Francis
Acute myeloid leukemia, a serious condition affecting stem cells, drives uncontrollable
myeloblast proliferation, leading to accumulation. Extensive research seeks rapid, effective …
myeloblast proliferation, leading to accumulation. Extensive research seeks rapid, effective …
Multi-combined 3D-QSAR, docking molecular and ADMET prediction of 5-azaindazole derivatives as LRRK2 tyrosine kinase inhibitors
The enzyme Leucine-rich repeat kinase 2 (LRRK2) has become a target of therapeutic
interest in Parkinson research. Athree-dimensional quantitative structure-activity …
interest in Parkinson research. Athree-dimensional quantitative structure-activity …
CoMFA, CoMSIA, Topomer CoMFA, HQSAR, molecular docking and molecular dynamics simulations study of triazine morpholino derivatives as mTOR inhibitors for …
Abstract mTOR has become a promising target for many types of cancer like breast, lung
and renal cell carcinoma. CoMFA, CoMSIA, Topomer CoMFA and HQSAR were performed …
and renal cell carcinoma. CoMFA, CoMSIA, Topomer CoMFA and HQSAR were performed …
[HTML][HTML] In silico exploration of aryl halides analogues as checkpoint kinase 1 inhibitors by using 3D QSAR, molecular docking study, and ADMET screening
Purpose: In this review, a set of aryl halides analogs were identified as potent checkpoint
kinase 1 (Chk1) inhibitors through a series of computer-aided drug design processes, to …
kinase 1 (Chk1) inhibitors through a series of computer-aided drug design processes, to …
QSAR studies in the discovery of novel type-II diabetic therapies
A Abuhammad, MO Taha - Expert opinion on drug discovery, 2016 - Taylor & Francis
Introduction: Type-II diabetes mellitus (T2DM) is a complex chronic disease that represents a
major therapeutic challenge. Despite extensive efforts in T2DM drug development, therapies …
major therapeutic challenge. Despite extensive efforts in T2DM drug development, therapies …
Design of SGLT2 inhibitors for the treatment of type 2 diabetes: a history driven by biology to chemistry
W Cai, L Jiang, Y Xie, Y Liu, W Liu… - Medicinal …, 2015 - ingentaconnect.com
A brief history of the design of sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors
is reviewed. The design of O-glucoside SGLT2 inhibitors by structural modification of …
is reviewed. The design of O-glucoside SGLT2 inhibitors by structural modification of …
3D-QSAR (CoMFA, CoMFA-RG, CoMSIA) and molecular docking study of thienopyrimidine and thienopyridine derivatives to explore structural requirements for aurora …
A Borisa, H Bhatt - European Journal of Pharmaceutical Sciences, 2015 - Elsevier
Aurora-B kinase plays a crucial role in cell cycle events and is identified as an important
factor in regulation of spindle check point assembly. Thus, it can be proved as an important …
factor in regulation of spindle check point assembly. Thus, it can be proved as an important …