Circadian disruption is pervasive and can occur at multiple organizational levels,
contributing to poor health outcomes at individual and population levels. Evidence points to …

The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …

The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …

Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however,
circadian rhythm disruptions are more severe in people with age-related neurodegenerative …

Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

Targeting tumour immunosuppressive microenvironment is a crucial strategy in
immunotherapy. However, the critical role of the tumour lymph node (LN) immune …

Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …

Neutrophils eliminate pathogens efficiently but can inflict severe damage to the host if they
over-activate within blood vessels. It is unclear how immunity solves the dilemma of …

Steady-state hematopoietic stem cells'(HSCs) self-renewal and differentiation toward their
mature progeny in the adult bone marrow is tightly regulated by cues from the …